[Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth

Jesse M. Walker, Alexis McEwan, Roxanne Pycko, Mary Lynn Tassotto, Christine Gottardo, John Th'ng, Ruiyao Wang, Gregory J. Spivak

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The [tris(pyrazolyl)methane]ruthenium complexes [(K3-tpm) RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K3-tpm)RuCl(LL)]PF6 [LL = K 2-dppe, K2-dppp, K2-dppb, (PMePh 2)2] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.

Original languageEnglish
Pages (from-to)4629-4633
Number of pages5
JournalEuropean Journal of Inorganic Chemistry
Issue number31
DOIs
Publication statusPublished - Nov 2009
Externally publishedYes

Keywords

  • Anticancer agents
  • Antiproliferative assays
  • Half-sandwich complexes
  • Ruthenium
  • Tris(pyrazolyl)methane

Cite this