Triple Network Model-Based Analysis on Abnormal Core Brain Functional Network Dynamics in Different Stage of Amnestic Mild Cognitive Impairment

Chenxi Li, Youjun Li, Jianqian Wu, Min Wu, Fang Peng*, Qiuling Chao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Amnestic mild cognitive impairment (aMCI) is considered to be a transitional stage between Alzheimer's disease (AD) and normal cognitive state because it has the same clinical symptoms as AD but with lower severity. Studies have confirmed that patients with aMCI are more likely to develop to AD. Although studies on resting state functional connectivity have revealed the abnormal organization of brain networks, the dynamic changes of the functional connectivity across the scans have been ignored. Objective: Dynamic functional connectivity is a novel method to reveal the temporal variation of brain networks. This paper aimed to investigate the dynamic characteristics of brain functional connectivity in the early and late phases of aMCI. Methods: Based on the 'triple network' model, we used the sliding time window approach to construct dynamical functional networks and then analyzed the dynamic characteristics of the functional connectivity across the entire scan. Results: The results showed that patients with aMCI had longer dwell times in weaker network connection than in the strong network. The transitions between different states become more frequent, and the stability of the patient's brain core network deteriorates. This study also found the correlation between the altered dynamic properties of the core functional networks and the patient's clinical Mini-Mental State Examination assessment scale sores. Conclusion: This study revealed that the characteristics of dynamic functional networks constructed by the core cognitive networks varied in distinct ways at different stages of aMCI, which could provide a new idea for exploring the neuro-mechanisms of neurological disorders.

Original languageEnglish
Pages (from-to)519-533
Number of pages15
JournalJournal of Alzheimer's Disease
Issue number2
Publication statusPublished - 1 Aug 2022
Externally publishedYes


  • Amnestic mild cognitive impairment
  • dynamic functional connectivity network
  • temporal variability
  • triple network


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