Total Synthesis of the Highly N-Methylated Peptide Jahanyne

Baijun Ye, Peng Jiang, Tingrong Zhang, Yahui Ding, Yuanjun Sun, Xin Hao, Lanshu Li, Liang Wang*, Yue Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc-N-Me-L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.

Original languageEnglish
Pages (from-to)6741-6747
Number of pages7
JournalJournal of Organic Chemistry
Issue number12
Publication statusPublished - 15 Jun 2018
Externally publishedYes


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