TY - JOUR
T1 - The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease
AU - Yue, Chunmei
AU - Feng, Su
AU - Chen, Yingying
AU - Jing, Naihe
N1 - Funding Information:
This study was supported by the National Taiwan University Hospital (111-A152). The National Taiwan University Hospital did not have a role in deciding study design, the collection, analysis, and interpretation of data, the writing of the report, or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obscure and intractable brain disorders, and currently, there are no effective therapies for it. Convincing evidence indicates that the irreversible decline of cognitive abilities in patients coincides with the deterioration and degeneration of neurons and synapses in the AD brain. Human neural stem cells (NSCs) hold the potential to functionally replace lost neurons, reinforce impaired synaptic networks, and repair the damaged AD brain. They have therefore received extensive attention as a possible source of donor cells for cellular replacement therapies for AD. Here, we review the progress in NSC-based transplantation studies in animal models of AD and assess the therapeutic advantages and challenges of human NSCs as donor cells. We then formulate a promising transplantation approach for the treatment of human AD, which would help to explore the disease-modifying cellular therapeutic strategy for the treatment of human AD.
AB - Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obscure and intractable brain disorders, and currently, there are no effective therapies for it. Convincing evidence indicates that the irreversible decline of cognitive abilities in patients coincides with the deterioration and degeneration of neurons and synapses in the AD brain. Human neural stem cells (NSCs) hold the potential to functionally replace lost neurons, reinforce impaired synaptic networks, and repair the damaged AD brain. They have therefore received extensive attention as a possible source of donor cells for cellular replacement therapies for AD. Here, we review the progress in NSC-based transplantation studies in animal models of AD and assess the therapeutic advantages and challenges of human NSCs as donor cells. We then formulate a promising transplantation approach for the treatment of human AD, which would help to explore the disease-modifying cellular therapeutic strategy for the treatment of human AD.
KW - Alzheimer's disease
KW - Brain disorders
KW - Brain region-specific transplantation
KW - Cognitive ability
KW - Neural subtype-specific transplantation
KW - Stem cell-based replacement therapy
UR - http://www.scopus.com/inward/record.url?scp=85137484597&partnerID=8YFLogxK
U2 - 10.1186/s13619-022-00128-5
DO - 10.1186/s13619-022-00128-5
M3 - Review article
AN - SCOPUS:85137484597
SN - 2045-9769
VL - 11
JO - Cell Regeneration
JF - Cell Regeneration
IS - 1
M1 - 28
ER -
