TY - JOUR
T1 - The smell of "anxiety"
T2 - Behavioral modulation by experimental anosmia in zebrafish
AU - Abreu, Murilo S.
AU - Giacomini, Ana C.V.V.
AU - Kalueff, Allan V.
AU - Barcellos, Leonardo J.G.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress also paralleling cortisol responses in zebrafish. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors and physiology in adult zebrafish.
AB - Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress also paralleling cortisol responses in zebrafish. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors and physiology in adult zebrafish.
KW - Fluoxetine
KW - Food odor
KW - Novel tank
KW - Olfactory sense
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=84956598492&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2016.01.030
DO - 10.1016/j.physbeh.2016.01.030
M3 - Article
C2 - 26821184
AN - SCOPUS:84956598492
SN - 0031-9384
VL - 157
SP - 67
EP - 71
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -