The serotonergic system of zebrafish: Genomics, neuroanatomy and neuropharmacology

Caio Maximino; Monica Gomes; Juliana Araujo; Karen Renata Matos Oliveira; Anderson Manoel Herculano; Adam Michael Stewart; Evan J. Kyzar; Jonathan Cachat; Allan V. Kalueff

The serotonergic system of zebrafish: Genomics, neuroanatomy and neuropharmacology

Caio Maximino^*, Monica Gomes, Juliana Araujo, Karen Renata Matos Oliveira, Anderson Manoel Herculano, Adam Michael Stewart, Evan J. Kyzar, Jonathan Cachat, Allan V. Kalueff

^*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

18 Citations (Scopus)

Abstract

The serotonergic system is highly conserved in vertebrate species, including zebrafish. In spite of a genome duplication in teleost fish (which altered the number of genes encoding proteins related to synthesis, transport and signaling within the serotonergic system), the expression pattern of these proteins in zebrafish is similar to other vertebrates. Pharmacological manipulations of the serotonergic system also produce similar behavioral and neuroendocrinological effects in zebrafish and mammals, suggesting that zebrafish represent a promising model for drug discovery and translational research focusing on central serotonergic mechanisms.

Original language	English
Title of host publication	Serotonin
Subtitle of host publication	Biosynthesis, Regulation and Health Implications
Publisher	Nova Science Publishers, Inc.
Pages	53-67
Number of pages	15
ISBN (Print)	9781624176364
Publication status	Published - Mar 2013
Externally published	Yes

Cite this

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AU - Araujo, Juliana

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AU - Herculano, Anderson Manoel

AU - Stewart, Adam Michael

AU - Kyzar, Evan J.

AU - Cachat, Jonathan

AU - Kalueff, Allan V.

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The serotonergic system of zebrafish: Genomics, neuroanatomy and neuropharmacology

Abstract

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