The role of vitamins in neurodegenerative disease: An update

Sachchida Nand Rai, Payal Singh, Harry W.M. Steinbusch, Emanuel Vamanu*, Ghulam Ashraf, Mohan Prasad Singh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)

Abstract

Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeo-static balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Hunt-ington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water-and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The de-tailed mechanism of action of both water-and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

Original languageEnglish
Article number1284
JournalBiomedicines
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2021
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Huntington disease
  • Neurodegenerative disease
  • Parkinson’s disease
  • Prion disease
  • Vitamins

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