The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease

Toufik Abdul-Rahman*, Shankhaneel Ghosh, Jacob B. Kalmanovich, Andrew Wireko Awuah, Marija Zivcevska, Samar Khalifa, Esther Edet Bassey, Namarig Alnil Ali, Matheus Mendes dos Santos Ferreira, Tungki Pratama Umar, Neil Garg, Victor Nnanna Nweze, Venkata Sai Sulekhya Inturu, Maya Magdy Abdelwahab, Sneha Kurian, Athanasios Alexiou*, Mohammed Alfaleh, Thamer M.A. Alqurashi, Ghulam Md Ashraf*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their surroundings. The retromer complex is a complex composed of nexin proteins and peptides that play a vital role in the endosomal pathway of membrane trafficking. In humans, any interference in normal membrane trafficking or retromer complex can cause profound changes such as those seen in neurodegenerative disorders such as Alzheimer's and Parkinson's. Several studies have explored the potential causative mechanisms in developing both disease processes; however, the role of retromer trafficking in their pathogenesis is becoming increasingly significant with promising therapeutic applications. This manuscript describes the processes involved in membrane transport and the roles of the retromer in the onset and progression of Alzheimer's and Parkinson's. Moreover, we will also explore how these aberrant mechanisms may serve as possible avenues for treatment development in both diseases and the prospect of its future application.

Original languageEnglish
Article numbere25261
JournalJournal of Neuroscience Research
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 2024
Externally publishedYes

Keywords

  • Alzheimer's disease
  • membrane trafficking
  • neurodegenerative disorders
  • Parkinson's disease
  • retromer

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