TY - JOUR
T1 - The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease
AU - Abdul-Rahman, Toufik
AU - Ghosh, Shankhaneel
AU - Kalmanovich, Jacob B.
AU - Awuah, Andrew Wireko
AU - Zivcevska, Marija
AU - Khalifa, Samar
AU - Bassey, Esther Edet
AU - Ali, Namarig Alnil
AU - Ferreira, Matheus Mendes dos Santos
AU - Umar, Tungki Pratama
AU - Garg, Neil
AU - Nweze, Victor Nnanna
AU - Inturu, Venkata Sai Sulekhya
AU - Abdelwahab, Maya Magdy
AU - Kurian, Sneha
AU - Alexiou, Athanasios
AU - Alfaleh, Mohammed
AU - Alqurashi, Thamer M.A.
AU - Ashraf, Ghulam Md
N1 - Publisher Copyright:
© 2023 Wiley Periodicals LLC.
PY - 2024/1
Y1 - 2024/1
N2 - Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their surroundings. The retromer complex is a complex composed of nexin proteins and peptides that play a vital role in the endosomal pathway of membrane trafficking. In humans, any interference in normal membrane trafficking or retromer complex can cause profound changes such as those seen in neurodegenerative disorders such as Alzheimer's and Parkinson's. Several studies have explored the potential causative mechanisms in developing both disease processes; however, the role of retromer trafficking in their pathogenesis is becoming increasingly significant with promising therapeutic applications. This manuscript describes the processes involved in membrane transport and the roles of the retromer in the onset and progression of Alzheimer's and Parkinson's. Moreover, we will also explore how these aberrant mechanisms may serve as possible avenues for treatment development in both diseases and the prospect of its future application.
AB - Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their surroundings. The retromer complex is a complex composed of nexin proteins and peptides that play a vital role in the endosomal pathway of membrane trafficking. In humans, any interference in normal membrane trafficking or retromer complex can cause profound changes such as those seen in neurodegenerative disorders such as Alzheimer's and Parkinson's. Several studies have explored the potential causative mechanisms in developing both disease processes; however, the role of retromer trafficking in their pathogenesis is becoming increasingly significant with promising therapeutic applications. This manuscript describes the processes involved in membrane transport and the roles of the retromer in the onset and progression of Alzheimer's and Parkinson's. Moreover, we will also explore how these aberrant mechanisms may serve as possible avenues for treatment development in both diseases and the prospect of its future application.
KW - Alzheimer's disease
KW - membrane trafficking
KW - neurodegenerative disorders
KW - Parkinson's disease
KW - retromer
UR - http://www.scopus.com/inward/record.url?scp=85177854057&partnerID=8YFLogxK
U2 - 10.1002/jnr.25261
DO - 10.1002/jnr.25261
M3 - Review article
C2 - 38284858
AN - SCOPUS:85177854057
SN - 0360-4012
VL - 102
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 1
M1 - e25261
ER -