TY - JOUR
T1 - The role of Aquaporins in tumorigenesis
T2 - implications for therapeutic development
AU - Bhattacharjee, Arkadyuti
AU - Jana, Ankit
AU - Bhattacharjee, Swagato
AU - Mitra, Sankalan
AU - De, Swagata
AU - Alghamdi, Badrah S.
AU - Alam, Mohammad Zubair
AU - Mahmoud, Ahmad Bakur
AU - Al Shareef, Zainab
AU - Abdel-Rahman, Wael M.
AU - Woon-Khiong, Chan
AU - Alexiou, Athanasios
AU - Papadakis, Marios
AU - Ashraf, Ghulam Md
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes. Tumour cells of varying sources express AQPs significantly, especially in malignant tumours with a high propensity for metastasis. New insights into the roles of AQPs in cell migration and proliferation reinforce the notion that AQPs are crucial players in tumour biology. AQPs have recently been shown to be a powerful tool in the fight against pathogenic antibodies and metastatic cell migration, despite the fact that the molecular processes of aquaporins in pathology are not entirely established. In this review, we shall discuss the several ways in which AQPs are expressed in the body, the unique roles they play in tumorigenesis, and the novel therapeutic approaches that could be adopted to treat carcinoma.
AB - Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes. Tumour cells of varying sources express AQPs significantly, especially in malignant tumours with a high propensity for metastasis. New insights into the roles of AQPs in cell migration and proliferation reinforce the notion that AQPs are crucial players in tumour biology. AQPs have recently been shown to be a powerful tool in the fight against pathogenic antibodies and metastatic cell migration, despite the fact that the molecular processes of aquaporins in pathology are not entirely established. In this review, we shall discuss the several ways in which AQPs are expressed in the body, the unique roles they play in tumorigenesis, and the novel therapeutic approaches that could be adopted to treat carcinoma.
KW - Aquaporins
KW - Cancer
KW - Carcinoma
KW - Therapeutic target
KW - Tumours
KW - Water channel
UR - http://www.scopus.com/inward/record.url?scp=85184794422&partnerID=8YFLogxK
U2 - 10.1186/s12964-023-01459-9
DO - 10.1186/s12964-023-01459-9
M3 - Review article
C2 - 38336645
AN - SCOPUS:85184794422
SN - 1478-811X
VL - 22
JO - Cell Communication and Signaling
JF - Cell Communication and Signaling
IS - 1
M1 - 106
ER -