The Function of the Metals in Regulating Epigenetics During Parkinson’s Disease

Xiangzhen Wei, Menghua Cai, Lifang Jin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Parkinson’s means Parkinson’s disease, a chronic degenerative disease of central nervous system. The main area which is affected by this disease is motor system. Since it firstly founded by James Parkinson in his 1817 publication, nowadays, people still have lots of questions about this disease. This review mainly summarizes the epigenetics of Parkinson’s. DNA methylation is one of the epigenetic mechanisms of Parkinson’s. During the development of disease, global hypomethylation, and hypermethylation happen in different areas of patients. Another epigenetic mechanism is histone modification. People believe that some metals can induce Parkinson’s disease by modulating epigenetic mechanisms. This review summarizes the relationships between different metals and Parkinson’s disease. However, the specific roles of most metals in epigenetics are still unknown, which need further research.

Original languageEnglish
Article number616083
JournalFrontiers in Genetics
Volume11
DOIs
Publication statusPublished - 2 Feb 2021
Externally publishedYes

Keywords

  • DNA methylation
  • epigenetic
  • metal
  • Parkinson’s disease
  • synucleinopathy

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