The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma

Lei Shi, Pei Liu, Jing Wu, Lun Ma, Han Zheng, Michael P. Antosh, Haiyan Zhang, Bo Wang, Wei Chen, Xiuli Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT. The dark toxicity and cytotoxicity were studied in vitro. Tumor volume, microvessel density and acute toxicity of mice were evaluated in vivo. Results: Without x-ray irradiation, copper-cysteamine nanoparticles were nontoxic for keratinocyte cells. XL50 cells (SCC) were more sensitive to X-PDT than B16F10 cells (melanoma). X-PDT successfully inhibited the growth of SCC in vivo (p < 0.05), while the B16F10 melanoma was resistant. Microvessel density in SCC tissue was remarkably reduced (p < 0.05). No obvious acute toxicity reaction was observed. Conclusion: X-PDT is a safe and effective treatment for SCC.

Original languageEnglish
Pages (from-to)2027-2043
Number of pages17
Issue number15
Publication statusPublished - 2019
Externally publishedYes


  • copper-cysteamine nanoparticle
  • melanoma
  • microvessel density
  • photodynamic therapy
  • squamous cell carcinoma (SCC)
  • x-ray


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