The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

Barbara D. Fontana, Nathana J. Mezzomo, Allan V. Kalueff*, Denis B. Rosemberg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

185 Citations (Scopus)

Abstract

Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.

Original languageEnglish
Pages (from-to)157-171
Number of pages15
JournalExperimental Neurology
Volume299
DOIs
Publication statusPublished - Jan 2018
Externally publishedYes

Keywords

  • Brain function
  • Neurological diseases
  • Neuropsychopharmacology
  • Psychiatric disorder
  • Zebrafish

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