The CD226 gene in susceptibility of type 1 diabetes

K. Douroudis; V. Nemvalts; T. Rajasalu; K. Kisand; R. Uibo

doi:10.1111/j.1399-0039.2009.01320.x

The CD226 gene in susceptibility of type 1 diabetes

K. Douroudis, V. Nemvalts, T. Rajasalu, K. Kisand, R. Uibo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to β-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.

Original language	English
Pages (from-to)	417-419
Number of pages	3
Journal	Tissue Antigens
Volume	74
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-0039.2009.01320.x
Publication status	Published - Nov 2009
Externally published	Yes

Keywords

CD226 gene
Single nucleotide polymorphism (SNP)
Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1399-0039.2009.01320.x

Cite this

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title = "The CD226 gene in susceptibility of type 1 diabetes",

abstract = "The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to β-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.",

keywords = "CD226 gene, Single nucleotide polymorphism (SNP), Type 1 diabetes",

author = "K. Douroudis and V. Nemvalts and T. Rajasalu and K. Kisand and R. Uibo",

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AU - Douroudis, K.

AU - Nemvalts, V.

AU - Rajasalu, T.

AU - Kisand, K.

AU - Uibo, R.

PY - 2009/11

Y1 - 2009/11

N2 - The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to β-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.

AB - The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to β-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.

KW - CD226 gene

KW - Single nucleotide polymorphism (SNP)

KW - Type 1 diabetes

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JO - Tissue Antigens

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IS - 5

ER -

The CD226 gene in susceptibility of type 1 diabetes

Abstract

Keywords

UN SDGs

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