The CD226 gene in susceptibility of type 1 diabetes

K. Douroudis, V. Nemvalts, T. Rajasalu, K. Kisand, R. Uibo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to β-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.

Original languageEnglish
Pages (from-to)417-419
Number of pages3
JournalTissue Antigens
Issue number5
Publication statusPublished - Nov 2009
Externally publishedYes


  • CD226 gene
  • Single nucleotide polymorphism (SNP)
  • Type 1 diabetes


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