The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

J. Park, S. Kunjibettu, S. B. McMahon, M. D. Cole*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)


The ATM-related TRRAP protein is a component of several different histone acetyltransferase (HAT) complexes but lacks the kinase activity characteristic of other ATM family members. We identified a novel function for this evolutionarily conserved domain in its requirement for the assembly of a functional HAT complex. Ectopic expression of TRRAP protein with a mutation in the ATM-related domain inhibits Myc-mediated oncogenic transformation. The Myc-binding region of TRRAP maps to a separable domain, and ectopic expression of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.

Original languageEnglish
Pages (from-to)1619-1624
Number of pages6
JournalGenes and Development
Issue number13
Publication statusPublished - 1 Jul 2001
Externally publishedYes


  • ATM domain
  • Histone acetyltransferase
  • Myc
  • Oncogenesis

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