Thalamic calcification in vitamin D receptor knockout mice

Allan Kalueff*, Elena Loseva, Hannu Haapasalo, Immo Rantala, Jaakko Keranen, Yan Ru Lou, Anna Minasyan, Tiina Keisala, Susanna Miettinen, Marianne Kuuslahti, Pentii Tuchimaa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies. These results are consistent with clinical findings showing brain calcification in patients with vitamin D deficiency. Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification.

Original languageEnglish
Pages (from-to)717-721
Number of pages5
Issue number7
Publication statusPublished - May 2006
Externally publishedYes


  • Knockout mice
  • Laminated bodies
  • Thalamic calcification
  • Vitamin D receptors


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