Tgf‐β/smad signalling in neurogenesis: Implications for neuropsychiatric diseases

Lih Fhung Hiew, Chi Him Poon, Heng Ze You, Lee Wei Lim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

TGF‐β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF‐β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF‐β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF‐β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.

Original languageEnglish
Article number1382
JournalCells
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2021
Externally publishedYes

Keywords

  • Depression
  • Neurogenesis
  • Smad
  • Stress
  • TGF‐β

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