Abstract
TGF‐β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF‐β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF‐β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF‐β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.
Original language | English |
---|---|
Article number | 1382 |
Journal | Cells |
Volume | 10 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2021 |
Externally published | Yes |
Keywords
- Depression
- Neurogenesis
- Smad
- Stress
- TGF‐β