Tgf‐β/smad signalling in neurogenesis: Implications for neuropsychiatric diseases

Lih Fhung Hiew; Chi Him Poon; Heng Ze You; Lee Wei Lim

doi:10.3390/cells10061382

Tgf‐β/smad signalling in neurogenesis: Implications for neuropsychiatric diseases

Lih Fhung Hiew, Chi Him Poon, Heng Ze You, Lee Wei Lim^*

^*Corresponding author for this work

The University of Hong Kong

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

TGF‐β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF‐β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF‐β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF‐β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.

Original language	English
Article number	1382
Journal	Cells
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/cells10061382
Publication status	Published - Jun 2021
Externally published	Yes

Keywords

Depression
Neurogenesis
Smad
Stress
TGF‐β

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10.3390/cells10061382

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title = "Tgf‐β/smad signalling in neurogenesis: Implications for neuropsychiatric diseases",

abstract = "TGF‐β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF‐β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF‐β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF‐β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.",

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T2 - Implications for neuropsychiatric diseases

AU - Hiew, Lih Fhung

AU - Poon, Chi Him

AU - You, Heng Ze

AU - Lim, Lee Wei

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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N2 - TGF‐β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF‐β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF‐β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF‐β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.

AB - TGF‐β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF‐β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF‐β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF‐β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.

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KW - Neurogenesis

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KW - Stress

KW - TGF‐β

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Tgf‐β/smad signalling in neurogenesis: Implications for neuropsychiatric diseases

Abstract

Keywords

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