TY - JOUR
T1 - TF and TCF4 gene polymorphisms are linked to autism spectrum disorder
T2 - a case–control study
AU - Azmerin, Maria
AU - Hussain, Md Saddam
AU - Aziz, Md Abdul
AU - Barek, Md Abdul
AU - Begum, Mobashera
AU - Sen, Niloy
AU - Rahman, Md Abdur
AU - Shahriar, Mohammad
AU - Baeesa, Saleh Salem
AU - Ashraf, Ghulam Md
AU - Islam, Mohammad Safiqul
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/11
Y1 - 2022/11
N2 - Objective: Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case–control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively. Methods: Ninety-six children with ASD and 118 healthy children were recruited and polymerase chain reaction–restriction fragment length polymorphism technique was applied for genotyping. Results: The frequencies of the mutant allele G were 48% and 44% for the rs1867503 and rs9951150 polymorphisms, respectively. In our analysis, both TF and TCF4 polymorphisms were associated with an increased risk of developing ASD. AG heterozygotes (OR = 3.18), GG mutant homozygotes (OR = 2.62), AG + GG combined genotypes (OR = 2.98), and G mutant alleles of TF rs1867503 (OR = 1.94) were associated with a significantly elevated risk of ASD. Likewise, AG heterozygotes (OR = 2.92), GG mutant homozygotes (OR = 2.36), AG + GG combined genotypes (OR = 2.72), and G minor alleles of TCF4 rs9951150 (OR = 1.92) were associated with a significantly elevated risk of ASD. Conclusions: Our results indicate that TF rs1867503 and TCF4 rs9951150 polymorphisms may be strongly associated with the development of ASD in Bangladeshi children.
AB - Objective: Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case–control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively. Methods: Ninety-six children with ASD and 118 healthy children were recruited and polymerase chain reaction–restriction fragment length polymorphism technique was applied for genotyping. Results: The frequencies of the mutant allele G were 48% and 44% for the rs1867503 and rs9951150 polymorphisms, respectively. In our analysis, both TF and TCF4 polymorphisms were associated with an increased risk of developing ASD. AG heterozygotes (OR = 3.18), GG mutant homozygotes (OR = 2.62), AG + GG combined genotypes (OR = 2.98), and G mutant alleles of TF rs1867503 (OR = 1.94) were associated with a significantly elevated risk of ASD. Likewise, AG heterozygotes (OR = 2.92), GG mutant homozygotes (OR = 2.36), AG + GG combined genotypes (OR = 2.72), and G minor alleles of TCF4 rs9951150 (OR = 1.92) were associated with a significantly elevated risk of ASD. Conclusions: Our results indicate that TF rs1867503 and TCF4 rs9951150 polymorphisms may be strongly associated with the development of ASD in Bangladeshi children.
KW - Autism spectrum disorder
KW - genetic polymorphism
KW - mutant allele G
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - TCF4 rs9951150
KW - TF rs1867503
UR - http://www.scopus.com/inward/record.url?scp=85143053637&partnerID=8YFLogxK
U2 - 10.1177/03000605221138492
DO - 10.1177/03000605221138492
M3 - Article
C2 - 36448207
AN - SCOPUS:85143053637
SN - 0300-0605
VL - 50
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 11
ER -