Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer

Nagendra Sastry Yarla; Olga Sukocheva; Ilaria Peluso; Swathi Putta; Pallaval Veera Bramhachari; Rajesh Yadala; Dinesh K. Tiwari; Srinivas Jagarlamudi; Luciana Scotti; Marcus T. Scotti; Marcella Reale; Mohammad Amjad Kamal; Ashraf Ghulam; Bechan Sharma; Madhukiran Parvathaneni; Chinthalapally V. Rao; Mastan Mannarapu; Anupam Bishayee

doi:10.1007/978-981-10-6728-0_30

Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer

Nagendra Sastry Yarla^*, Olga Sukocheva, Ilaria Peluso, Swathi Putta, Pallaval Veera Bramhachari, Rajesh Yadala, Dinesh K. Tiwari, Srinivas Jagarlamudi, Luciana Scotti, Marcus T. Scotti, Marcella Reale, Mohammad Amjad Kamal, Ashraf Ghulam, Bechan Sharma, Madhukiran Parvathaneni, Chinthalapally V. Rao, Mastan Mannarapu, Anupam Bishayee

^*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Pancreatic cancer is one of the foremost causes of cancer-related death in the United States and worldwide. Nuclear factor-kappa B (NF-κB) is a transcription factor which plays a pivotal involvement in pancreatic cancer owing to its connection at the downstream stage of many signaling cascades including arachidonic acid (AA) pathway. AA cascade is an upstream pathway and regulator of NF-κB pathway. Moreover, NF-κB can bind to the cis-acting elements in the promoter of phospholipase A₂s, cyclooxygenases, and lipoxygenases, and these pathways are upregulated in a variety of cancers. Several investigators have proved that AA pathway-associated NF-κB has key role in pathophysiology of pancreatic cancer and has been considered as a vital therapeutic target. Several phytochemicals have been explored as novel therapeutic and preventive agents by targeting AA cascade-associated NF-κB pathway. In this chapter, the role of AA cascade-associated NF-κB pathway in pancreatic cancer has been reviewed and discussed about plant-derived inhibitors of this pathway for the prevention and the therapy of pancreatic cancer.

Original language	English
Title of host publication	Role of Transcription Factors in Gastrointestinal Malignancies
Publisher	Springer Singapore
Pages	401-409
Number of pages	9
ISBN (Electronic)	9789811067280
ISBN (Print)	9789811067273
DOIs	https://doi.org/10.1007/978-981-10-6728-0_30
Publication status	Published - 1 Jan 2018
Externally published	Yes

Keywords

Arachidonic acid pathway
Natural products
NF-κB
Pancreatic cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-10-6728-0_30

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Yarla, N. S., Sukocheva, O., Peluso, I., Putta, S., Bramhachari, P. V., Yadala, R., Tiwari, D. K., Jagarlamudi, S., Scotti, L., Scotti, M. T., Reale, M., Kamal, M. A., Ghulam, A., Sharma, B., Parvathaneni, M., Rao, C. V., Mannarapu, M., & Bishayee, A. (2018). Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 401-409). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_30

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title = "Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer",

abstract = "Pancreatic cancer is one of the foremost causes of cancer-related death in the United States and worldwide. Nuclear factor-kappa B (NF-κB) is a transcription factor which plays a pivotal involvement in pancreatic cancer owing to its connection at the downstream stage of many signaling cascades including arachidonic acid (AA) pathway. AA cascade is an upstream pathway and regulator of NF-κB pathway. Moreover, NF-κB can bind to the cis-acting elements in the promoter of phospholipase A2s, cyclooxygenases, and lipoxygenases, and these pathways are upregulated in a variety of cancers. Several investigators have proved that AA pathway-associated NF-κB has key role in pathophysiology of pancreatic cancer and has been considered as a vital therapeutic target. Several phytochemicals have been explored as novel therapeutic and preventive agents by targeting AA cascade-associated NF-κB pathway. In this chapter, the role of AA cascade-associated NF-κB pathway in pancreatic cancer has been reviewed and discussed about plant-derived inhibitors of this pathway for the prevention and the therapy of pancreatic cancer.",

keywords = "Arachidonic acid pathway, Natural products, NF-κB, Pancreatic cancer",

author = "Yarla, {Nagendra Sastry} and Olga Sukocheva and Ilaria Peluso and Swathi Putta and Bramhachari, {Pallaval Veera} and Rajesh Yadala and Tiwari, {Dinesh K.} and Srinivas Jagarlamudi and Luciana Scotti and Scotti, {Marcus T.} and Marcella Reale and Kamal, {Mohammad Amjad} and Ashraf Ghulam and Bechan Sharma and Madhukiran Parvathaneni and Rao, {Chinthalapally V.} and Mastan Mannarapu and Anupam Bishayee",

note = "Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2017.",

year = "2018",

month = jan,

day = "1",

doi = "10.1007/978-981-10-6728-0_30",

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Yarla, NS, Sukocheva, O, Peluso, I, Putta, S, Bramhachari, PV, Yadala, R, Tiwari, DK, Jagarlamudi, S, Scotti, L, Scotti, MT, Reale, M, Kamal, MA, Ghulam, A, Sharma, B, Parvathaneni, M, Rao, CV, Mannarapu, M & Bishayee, A 2018, Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer. in Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, pp. 401-409. https://doi.org/10.1007/978-981-10-6728-0_30

TY - CHAP

T1 - Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer

AU - Yarla, Nagendra Sastry

AU - Sukocheva, Olga

AU - Peluso, Ilaria

AU - Putta, Swathi

AU - Bramhachari, Pallaval Veera

AU - Yadala, Rajesh

AU - Tiwari, Dinesh K.

AU - Jagarlamudi, Srinivas

AU - Scotti, Luciana

AU - Scotti, Marcus T.

AU - Reale, Marcella

AU - Kamal, Mohammad Amjad

AU - Ghulam, Ashraf

AU - Sharma, Bechan

AU - Parvathaneni, Madhukiran

AU - Rao, Chinthalapally V.

AU - Mannarapu, Mastan

AU - Bishayee, Anupam

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Pancreatic cancer is one of the foremost causes of cancer-related death in the United States and worldwide. Nuclear factor-kappa B (NF-κB) is a transcription factor which plays a pivotal involvement in pancreatic cancer owing to its connection at the downstream stage of many signaling cascades including arachidonic acid (AA) pathway. AA cascade is an upstream pathway and regulator of NF-κB pathway. Moreover, NF-κB can bind to the cis-acting elements in the promoter of phospholipase A2s, cyclooxygenases, and lipoxygenases, and these pathways are upregulated in a variety of cancers. Several investigators have proved that AA pathway-associated NF-κB has key role in pathophysiology of pancreatic cancer and has been considered as a vital therapeutic target. Several phytochemicals have been explored as novel therapeutic and preventive agents by targeting AA cascade-associated NF-κB pathway. In this chapter, the role of AA cascade-associated NF-κB pathway in pancreatic cancer has been reviewed and discussed about plant-derived inhibitors of this pathway for the prevention and the therapy of pancreatic cancer.

AB - Pancreatic cancer is one of the foremost causes of cancer-related death in the United States and worldwide. Nuclear factor-kappa B (NF-κB) is a transcription factor which plays a pivotal involvement in pancreatic cancer owing to its connection at the downstream stage of many signaling cascades including arachidonic acid (AA) pathway. AA cascade is an upstream pathway and regulator of NF-κB pathway. Moreover, NF-κB can bind to the cis-acting elements in the promoter of phospholipase A2s, cyclooxygenases, and lipoxygenases, and these pathways are upregulated in a variety of cancers. Several investigators have proved that AA pathway-associated NF-κB has key role in pathophysiology of pancreatic cancer and has been considered as a vital therapeutic target. Several phytochemicals have been explored as novel therapeutic and preventive agents by targeting AA cascade-associated NF-κB pathway. In this chapter, the role of AA cascade-associated NF-κB pathway in pancreatic cancer has been reviewed and discussed about plant-derived inhibitors of this pathway for the prevention and the therapy of pancreatic cancer.

KW - Arachidonic acid pathway

KW - Natural products

KW - NF-κB

KW - Pancreatic cancer

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U2 - 10.1007/978-981-10-6728-0_30

DO - 10.1007/978-981-10-6728-0_30

M3 - Chapter

AN - SCOPUS:85046399067

SN - 9789811067273

SP - 401

EP - 409

BT - Role of Transcription Factors in Gastrointestinal Malignancies

PB - Springer Singapore

ER -

Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer

Abstract

Keywords

UN SDGs

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