Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor

Yi Lin, Alain Favre-Réguillon, Stéphane Pellet-Rostaing*, Marc Lemaire

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2,4-[bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22% overall yield from the starting 3-hydroxypyridine.

Original languageEnglish
Pages (from-to)3463-3466
Number of pages4
JournalTetrahedron Letters
Issue number19
Publication statusPublished - 7 May 2007
Externally publishedYes


  • Azamacrocycle
  • Mitsunobu reaction
  • PCTA
  • Thiol

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