Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry

Guolong Wu, Di Wang, Wei Zhu, Hong Shen, Haixia Liu*, Lei Fu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.

Original languageEnglish
Pages (from-to)12-21
Number of pages10
JournalSynthetic Communications
Issue number1
Publication statusPublished - 2 Jan 2019
Externally publishedYes


  • Amino alcohol
  • bridged bicyclic morpholine
  • compact module
  • medicinal chemistry

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