Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry

Guolong Wu; Di Wang; Wei Zhu; Hong Shen; Haixia Liu; Lei Fu

doi:10.1080/00397911.2018.1528615

Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry

Guolong Wu, Di Wang, Wei Zhu, Hong Shen, Haixia Liu^*, Lei Fu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.

Original language	English
Pages (from-to)	12-21
Number of pages	10
Journal	Synthetic Communications
Volume	49
Issue number	1
DOIs	https://doi.org/10.1080/00397911.2018.1528615
Publication status	Published - 2 Jan 2019
Externally published	Yes

Keywords

Amino alcohol
bridged bicyclic morpholine
compact module
medicinal chemistry

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10.1080/00397911.2018.1528615

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title = "Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry",

abstract = "The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.",

keywords = "Amino alcohol, bridged bicyclic morpholine, compact module, medicinal chemistry",

author = "Guolong Wu and Di Wang and Wei Zhu and Hong Shen and Haixia Liu and Lei Fu",

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AU - Wu, Guolong

AU - Wang, Di

AU - Zhu, Wei

AU - Shen, Hong

AU - Liu, Haixia

AU - Fu, Lei

PY - 2019/1/2

Y1 - 2019/1/2

N2 - The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.

AB - The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.

KW - Amino alcohol

KW - bridged bicyclic morpholine

KW - compact module

KW - medicinal chemistry

UR - http://www.scopus.com/inward/record.url?scp=85058451628&partnerID=8YFLogxK

U2 - 10.1080/00397911.2018.1528615

DO - 10.1080/00397911.2018.1528615

M3 - Article

AN - SCOPUS:85058451628

SN - 0039-7911

VL - 49

SP - 12

EP - 21

JO - Synthetic Communications

JF - Synthetic Communications

IS - 1

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Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry

Abstract

Keywords

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