Synthesis and antimicrobial evaluation of new benzofuran derivatives

Xizhen Jiang, Wenlu Liu, Wei Zhang, Faqin Jiang, Zhe Gao, Hao Zhuang, Lei Fu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 μg/mL), which were better than the control drugs.

Original languageEnglish
Pages (from-to)3526-3530
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Issue number8
Publication statusPublished - Aug 2011
Externally publishedYes


  • Anti-microorganism
  • Benzofuran
  • Stilbenoid
  • Synthesis


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