Synergistic effects of nanomedicine targeting TNFR2 and DNA demethylation inhibitor— An opportunity for cancer treatment

Mohammad A.I. Al-Hatamleh, E. A.R. Engku Nur Syafirah, Jennifer C. Boer, Khalid Ferji, Jean Luc Six, Xin Chen, Eyad Elkord, Magdalena Plebanski, Rohimah Mohamud*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Tumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, as well as immunosuppressive cells. There is increasingly evidence that TNFR2 expression in cancer microenvironment has significant implications in cancer progression, metastasis and immune evasion. Although nanomedicine has been extensively studied as a carrier of cancer immunotherapeutic agents, no study to date has investigated TNFR2-targeting nanomedicine in cancer treatment. From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. This perspective review discusses a novel therapeutic strategy based on nanomedicine that has the capacity to target TNFR2 along with inhibition of DNA demethylation. This approach may maximize the anti-cancer potential of nanomedicine-based immunotherapy and, consequently, markedly improve the outcomes of the management of patients with malignancy.

Original languageEnglish
Article number33
JournalCells
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2020
Externally publishedYes

Keywords

  • Immunosuppressive
  • Immunotherapy
  • Nanoparticles
  • Regulatory T cells
  • TNF

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