2-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated ketones under ligand-free and neutral conditions

Lei Zhang; Xiaomin Xie; Lei Fu; Zhaoguo Zhang

doi:10.1021/jo4001367

₂-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated ketones under ligand-free and neutral conditions

Lei Zhang, Xiaomin Xie, Lei Fu^*, Zhaoguo Zhang

^*Corresponding author for this work

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A simple and efficient Ru-catalyzed conjugate addition reaction of arylboronic acids to α,β-unsaturated ketones under neutral conditions without any additional ligands has been developed. This Ru(II)-catalytic system both fulfilled the inhibition of the β-hydride elimination in the catalytic cycle and minimized the protonolysis of arylboronic acids.

Original language	English
Pages (from-to)	3434-3437
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	78
Issue number	7
DOIs	https://doi.org/10.1021/jo4001367
Publication status	Published - 5 Apr 2013
Externally published	Yes

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10.1021/jo4001367

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title = "2-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated ketones under ligand-free and neutral conditions",

abstract = "A simple and efficient Ru-catalyzed conjugate addition reaction of arylboronic acids to α,β-unsaturated ketones under neutral conditions without any additional ligands has been developed. This Ru(II)-catalytic system both fulfilled the inhibition of the β-hydride elimination in the catalytic cycle and minimized the protonolysis of arylboronic acids.",

author = "Lei Zhang and Xiaomin Xie and Lei Fu and Zhaoguo Zhang",

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T1 - 2-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated ketones under ligand-free and neutral conditions

AU - Zhang, Lei

AU - Xie, Xiaomin

AU - Fu, Lei

AU - Zhang, Zhaoguo

PY - 2013/4/5

Y1 - 2013/4/5

N2 - A simple and efficient Ru-catalyzed conjugate addition reaction of arylboronic acids to α,β-unsaturated ketones under neutral conditions without any additional ligands has been developed. This Ru(II)-catalytic system both fulfilled the inhibition of the β-hydride elimination in the catalytic cycle and minimized the protonolysis of arylboronic acids.

AB - A simple and efficient Ru-catalyzed conjugate addition reaction of arylboronic acids to α,β-unsaturated ketones under neutral conditions without any additional ligands has been developed. This Ru(II)-catalytic system both fulfilled the inhibition of the β-hydride elimination in the catalytic cycle and minimized the protonolysis of arylboronic acids.

UR - http://www.scopus.com/inward/record.url?scp=84875920117&partnerID=8YFLogxK

U2 - 10.1021/jo4001367

DO - 10.1021/jo4001367

M3 - Article

C2 - 23448088

AN - SCOPUS:84875920117

SN - 0022-3263

VL - 78

SP - 3434

EP - 3437

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 7

ER -

2-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated ketones under ligand-free and neutral conditions

Abstract

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₂-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated ketones under ligand-free and neutral conditions