Study on preparation and release behavior of 5-fluorouracil hollow microcapsules

Hong Fei Wu*, Chuan Hua Lu, Jun Jun Xie, Xiao Wei Li, Tao Lu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


OBJECTIVE: To study a new preparation process of 5-fluorouracil hollow microcapsules, and to investigate the influence of porogen on the release behavior of microcapsules. METHODS: PEG was added to PVA, the capsule wall material, as porogen. Suspension interfacial cross-linking method was adopted to prepare 5-flurouracil hollow microcapsules. To optimize the preparation process of PVA microcapsules, the particle size, drug-loading rate, and encapsulation efficiency were examined. In order to study the effect of porogen, the total amount of in vitro drug release was examined. RESULTS: Microcapsules prepared by this process have completely hollow structure. The average diameter of the microcapsules was 22 μm. The drug- loading rate and encapsulation efficiency were 15.6% and 84.8%, respectively. For the porogen added microcapsules, the 24 h in vitro drug release rate was 93.2%. CONCLUSION: The suspension cross-linking method can be used to prepare hollow microcapsules. The hollow structure of microcapsules may increase drug-loading rate. When porogen is added in the wall material, incomplete drug release are overcame. The microcapsules has sustained release in vitro.

Original languageEnglish
Pages (from-to)761-765
Number of pages5
JournalChinese Pharmaceutical Journal
Issue number10
Publication statusPublished - 22 May 2011
Externally publishedYes


  • 5-fluorouracil
  • PEG
  • PVA microcapsules
  • Porogen
  • Suspension interface cross-linking method


Dive into the research topics of 'Study on preparation and release behavior of 5-fluorouracil hollow microcapsules'. Together they form a unique fingerprint.

Cite this