Abstract
OBJECTIVE: To study a new preparation process of 5-fluorouracil hollow microcapsules, and to investigate the influence of porogen on the release behavior of microcapsules. METHODS: PEG was added to PVA, the capsule wall material, as porogen. Suspension interfacial cross-linking method was adopted to prepare 5-flurouracil hollow microcapsules. To optimize the preparation process of PVA microcapsules, the particle size, drug-loading rate, and encapsulation efficiency were examined. In order to study the effect of porogen, the total amount of in vitro drug release was examined. RESULTS: Microcapsules prepared by this process have completely hollow structure. The average diameter of the microcapsules was 22 μm. The drug- loading rate and encapsulation efficiency were 15.6% and 84.8%, respectively. For the porogen added microcapsules, the 24 h in vitro drug release rate was 93.2%. CONCLUSION: The suspension cross-linking method can be used to prepare hollow microcapsules. The hollow structure of microcapsules may increase drug-loading rate. When porogen is added in the wall material, incomplete drug release are overcame. The microcapsules has sustained release in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 761-765 |
| Number of pages | 5 |
| Journal | Chinese Pharmaceutical Journal |
| Volume | 46 |
| Issue number | 10 |
| Publication status | Published - 22 May 2011 |
| Externally published | Yes |
Keywords
- 5-fluorouracil
- PEG
- PVA microcapsules
- Porogen
- Suspension interface cross-linking method