TY - JOUR
T1 - Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues
AU - Fosso, Marina
AU - AlFindee, Madher N.
AU - Zhang, Qian
AU - Nziko, Vincent De Paul Nzuwah
AU - Kawasaki, Yukie
AU - Shrestha, Sanjib K.
AU - Bearss, Jeremiah
AU - Gregory, Rylee
AU - Takemoto, Jon Y.
AU - Chang, Cheng Wei Tom
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Novel fungicides are urgently needed. It was recently reported that the attachment of an octyl group at the O-4″ position of kanamycin B converts this antibacterial aminoglycoside into a novel antifungal agent. To elucidate the structure-activity relationship (SAR) for this phenomenon, a lead compound FG03 with a hydroxyl group replacing the 3″-NH2 group of kanamycin B was synthesized. FG03's antifungal activity and synthetic scheme inspired the synthesis of a library of kanamycin B analogues alkylated at various hydroxyl groups. SAR studies of the library revealed that for antifungal activity the O-4″ position is the optimal site for attaching a linear alkyl chain and that the 3″-NH2 and 6″-OH groups of the kanamycin B parent molecule are not essential for antifungal activity. The discovery of lead compound, FG03, is an example of reviving clinically obsolete drugs like kanamycin by simple chemical modification and an alternative strategy for discovering novel antimicrobials.
AB - Novel fungicides are urgently needed. It was recently reported that the attachment of an octyl group at the O-4″ position of kanamycin B converts this antibacterial aminoglycoside into a novel antifungal agent. To elucidate the structure-activity relationship (SAR) for this phenomenon, a lead compound FG03 with a hydroxyl group replacing the 3″-NH2 group of kanamycin B was synthesized. FG03's antifungal activity and synthetic scheme inspired the synthesis of a library of kanamycin B analogues alkylated at various hydroxyl groups. SAR studies of the library revealed that for antifungal activity the O-4″ position is the optimal site for attaching a linear alkyl chain and that the 3″-NH2 and 6″-OH groups of the kanamycin B parent molecule are not essential for antifungal activity. The discovery of lead compound, FG03, is an example of reviving clinically obsolete drugs like kanamycin by simple chemical modification and an alternative strategy for discovering novel antimicrobials.
UR - http://www.scopus.com/inward/record.url?scp=84928920263&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.5b00248
DO - 10.1021/acs.joc.5b00248
M3 - Article
C2 - 25826012
AN - SCOPUS:84928920263
SN - 0022-3263
VL - 80
SP - 4398
EP - 4411
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 9
ER -