Abstract
A large number of neurodegenerative diseases, the age-related dementia, and the human frailty are caused, among others, from non-folding proteins and the aggregation of them leading to neuronal death. In the case of Alzheimer’s disease, a significant number of proteins like amyloid beta and tau seem to form unordered and problematic structures, leading through unknown mechanisms to pathological conditions and implications. Additionally, few studies have already shown the possibility of composing music sculptures retrieved from biological data, either for music audience or for cases of art therapy. In this study, we use a novel algorithm in order to present complex sound sculptures based on a hypothetical computerized interaction of amyloid beta and tau. The designed algorithm is completely adjustable, regarding several sound parameters, recognizing and emphasizing common patterns between the tested proteins for the generation of acoustic stimulus to the audience, and revealing Alzheimer’s complexity and tragedy.
Original language | English |
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Title of host publication | Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease |
Subtitle of host publication | Non-Pharmacological Therapies for Alzheimer's Disease |
Publisher | Springer Singapore |
Pages | 117-128 |
Number of pages | 12 |
ISBN (Electronic) | 9789811396366 |
ISBN (Print) | 9789811396359 |
DOIs | |
Publication status | Published - 1 Jan 2019 |
Externally published | Yes |
Keywords
- Alzheimer’s disease
- Amino acids
- Amyloid beta protein
- Art therapy
- Music neuroscience
- Musical instrument digital interface
- Neuroscience education
- Tau protein