Stereochemistry of hydroxylation during the conversion of α-ketoisocaproate to β-hydroxyisovalerate by 4-hydroxyphenylpyruvate dioxygenase

Robert M. Adlington, Jack E. Baldwin, Nicholas P. Crouch*, Meng Huee Lee, Colin H. MacKinnon, Diana R. Paul

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


4-Hydroxyphenylpyruvate dioxygenase catalyzes the oxidative decarboxylation and hydroxylation of α-ketoisocaproate 1 to β-hydroxyisovalerate 2 with retention of configuration during the hydroxylation step.

Original languageEnglish
Pages (from-to)2721-2724
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number22
Publication statusPublished - 19 Nov 1996
Externally publishedYes

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