Sleep disorders associated with Alzheimer's disease: A perspective

Anna Brzecka, Jerzy Leszek, Ghulam Md Ashraf, Maria Ejma, Marco F. Ávila-Rodriguez, Nagendra S. Yarla, Vadim V. Tarasov, Vladimir N. Chubarev, Anna N. Samsonova, George E. Barreto, Gjumrakch Aliev*

*Corresponding author for this work

Research output: Other contributionpeer-review

98 Citations (Scopus)

Abstract

Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-β. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD.

Original languageEnglish
TypeShort Survry
Media of outputJournal
EditionMAY
Volume12
DOIs
Publication statusPublished - 31 May 2018
Externally publishedYes

Publication series

NameFrontiers in Neuroscience
ISSN (Print)1662-4548

Keywords

  • AD
  • Diagnosis
  • Disturbance
  • Sleep disorders
  • Sleep-rhythm

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