Seven-transmembrane receptors: Crystals clarify

Zhi Liang Lu*, Jose W. Saldanha, Edward C. Hulme

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

156 Citations (Scopus)


The X-ray structure of the photoreceptor rhodopsin has provided the first atomic-resolution structure of a seven-transmembrane (7-TM) G-protein-coupled receptor. This has provided an improved template for interpreting the huge body of structure-activity, mutagenesis and affinity labelling data available for related 7-TM receptors, such as muscarinic acetylcholine receptors. Ligand contacts, and the intramolecular interactions that stabilize the ground state structure, can be identified with some degree of confidence. We now have a firm basis for attempts to predict the structure of the receptor-G-protein complex, and understand the mechanism by which the agonist-receptor complex activates the G protein.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalTrends in Pharmacological Sciences
Issue number3
Publication statusPublished - 1 Mar 2002
Externally publishedYes

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