Sensitive and Selective Electrochemical Determination of L-Cysteine Based on Cerium Oxide Nanofibers Modified Screen Printed Carbon Electrode

Fei Cao*, Qiuchen Dong, Caolong Li, Dongwook Kwak, Yikun Huang, Donghui Song, Yu Lei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


A novel L-cysteine (CysH) electrochemical sensor based on CeO2 nanofibers (NFs) modified screen printed carbon electrodes (SPCEs) was developed. The morphology and the structure of the as-prepared CeO2 NFs were first characterized using scanning electron microscopy (SEM) and X-ray diffraction pattern (XRD), respectively. The electrochemical and electrocatalytic performances of the CeO2 NFs modified SPCEs were then evaluated using cyclic voltammetry and amperometry. Experimental results showed that the CeO2 NFs modified SPCEs possess excellent electrocatalytic activity toward the detection of CysH. Specifically, the developed electrochemical sensor demonstrated a high sensitivity of 120 μA mM−1 cm−2, a low detection limit of 20 nM (signal to noise ratio of 3) and a wide linear range up to 200 μM for the determination of CysH, which are among the best values reported in literature. In addition, good selectivity and outstanding intra- and inter-electrode reproducibility have also been observed. Furthermore, the developed CysH sensor was applied to detect CysH spiked into human serum samples with remarkable accuracy. All these features indicate that CeO2 NFs hold great promise in the development of high performance electrochemical sensor for CysH.

Original languageEnglish
Pages (from-to)1133-1139
Number of pages7
Issue number6
Publication statusPublished - Jun 2018
Externally publishedYes


  • CeO nanofibers
  • L-cysteine
  • electrocatalytic oxidation
  • electrochemical sensor
  • electrospinning

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