Role of mediterranean diet in Parkinson's disease

Mohannad A. Almikhlafi; Badrah Alghamdi; Ghulam Md Ashraf

doi:10.1016/B978-0-323-89834-8.00001-5

Role of mediterranean diet in Parkinson's disease

Mohannad A. Almikhlafi, Badrah Alghamdi, Ghulam Md Ashraf

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

Abstract

Parkinson's disease (PD) is the most common neurodegenerative motor disorder that is caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mediterranean diet (MeDi) was found to be effective in multiple disorders including PD. However, the efficacy of this diet on Parkinson's disease depends on the adherence to the MeDi. High adherence to the diet was found to slow the disease progression, while low adherence was associated with the early appearance of PD symptoms. Dietary factors of MeDi such as polyunsaturated fatty acid (PUFA), olive oil, and vitamins were found to implicate the progression of PD. In general, their role in scavenging free radicals, antiinflammation, and inhibiting apoptosis is the main pathway responsible for the neuroprotective effect of MeDi. Those effects lead to the improvement of locomotor functions of PD.

Original language	English
Title of host publication	Diet and Nutrition in Neurological Disorders
Publisher	Elsevier
Pages	649-665
Number of pages	17
ISBN (Electronic)	9780323898348
ISBN (Print)	9780323915717
DOIs	https://doi.org/10.1016/B978-0-323-89834-8.00001-5
Publication status	Published - 1 Jan 2023
Externally published	Yes

Keywords

Antioxidant
Clinical trial
Dietary intervention
Mediterranean diet
Parkinson's disease

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10.1016/B978-0-323-89834-8.00001-5

Cite this

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abstract = "Parkinson's disease (PD) is the most common neurodegenerative motor disorder that is caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mediterranean diet (MeDi) was found to be effective in multiple disorders including PD. However, the efficacy of this diet on Parkinson's disease depends on the adherence to the MeDi. High adherence to the diet was found to slow the disease progression, while low adherence was associated with the early appearance of PD symptoms. Dietary factors of MeDi such as polyunsaturated fatty acid (PUFA), olive oil, and vitamins were found to implicate the progression of PD. In general, their role in scavenging free radicals, antiinflammation, and inhibiting apoptosis is the main pathway responsible for the neuroprotective effect of MeDi. Those effects lead to the improvement of locomotor functions of PD.",

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AU - Ashraf, Ghulam Md

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AB - Parkinson's disease (PD) is the most common neurodegenerative motor disorder that is caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mediterranean diet (MeDi) was found to be effective in multiple disorders including PD. However, the efficacy of this diet on Parkinson's disease depends on the adherence to the MeDi. High adherence to the diet was found to slow the disease progression, while low adherence was associated with the early appearance of PD symptoms. Dietary factors of MeDi such as polyunsaturated fatty acid (PUFA), olive oil, and vitamins were found to implicate the progression of PD. In general, their role in scavenging free radicals, antiinflammation, and inhibiting apoptosis is the main pathway responsible for the neuroprotective effect of MeDi. Those effects lead to the improvement of locomotor functions of PD.

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Role of mediterranean diet in Parkinson's disease

Abstract

Keywords

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