RNA methylation and diseases: Experimental results, databases, Web servers and computational models

Xing Chen*, Ya Zhou Sun, Hui Liu, Lin Zhang, Jian Qiang Li, Jia Meng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Ribonucleic acid RNA) methylation is a type of posttranscriptional modifications occurring in all kingdoms of life. It is strongly related to important biological process, thus making it linked to a number of human diseases. Owing to the development of high-throughput sequencing technology, plenty of achievement had been obtained in RNA methylation research recently. Meanwhile, various computational models have been developed to analyze and mining increasing RNA methylation data. In this review, we first made a brief introduction about eight types of most popular RNA methylation, the biological functions of RNA methylation, the relationship between RNA methylation and disease and five important RNA methylation-related diseases. The research of RNA methylation is based on sequencing data processing, and effective bioinformatics techniques can benefit better understanding of RNA methylation. We further introduced seven publicly available RNA methylation-related databases, and some important publicly available RNA-methylation-related Web servers and software for RNA methylation site identification, differential analysis and so on. Furthermore, we provided detailed analysis of the state-of-the-art computational models used in these Web servers and software. We also analyzed the limitations of these models and discussed the future directions of developing computational models for RNA methylation research.

Original languageEnglish
Article numberbbx142
Pages (from-to)896-917
Number of pages22
JournalBriefings in Bioinformatics
Volume20
Issue number3
DOIs
Publication statusPublished - 2 Nov 2017

Keywords

  • RNA methylation
  • Web server and software
  • biological function
  • computational model
  • database
  • disease

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