Abstract
DNA methylation is a common epigenetic process, which exists in many eukaryotes, such as animals and plants. It has the function of regulating gene expression and affecting the stability of genetic material. The unmethylated CpG dinucleotide, known as CGI, generally presents a local aggregation pattern in the genome. Abnormal methylation of CGI is often associated with cancer and abnormal growth. Therefore, it is of great significance to accurately identify CGI and predict its methylation state. This paper summarizes the current mainstream CGI computational recognition methods, analyzes their advantages and disadvantages, and discusses the future direction of CGI recognition algorithm research.
| Original language | English |
|---|---|
| Article number | 042026 |
| Journal | Journal of Physics: Conference Series |
| Volume | 1624 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 6 Nov 2020 |
| Externally published | Yes |
| Event | 2020 2nd International Conference on Computer Modeling, Simulation and Algorithm, CMSA 2020 - Beijing, China Duration: 21 Jun 2020 → 22 Jun 2020 |
