Review of CpG Island Recognition Algorithms

Yanning Cai*, Qian Dong, Anlan Li

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)

Abstract

DNA methylation is a common epigenetic process, which exists in many eukaryotes, such as animals and plants. It has the function of regulating gene expression and affecting the stability of genetic material. The unmethylated CpG dinucleotide, known as CGI, generally presents a local aggregation pattern in the genome. Abnormal methylation of CGI is often associated with cancer and abnormal growth. Therefore, it is of great significance to accurately identify CGI and predict its methylation state. This paper summarizes the current mainstream CGI computational recognition methods, analyzes their advantages and disadvantages, and discusses the future direction of CGI recognition algorithm research.

Original languageEnglish
Article number042026
JournalJournal of Physics: Conference Series
Volume1624
Issue number4
DOIs
Publication statusPublished - 6 Nov 2020
Externally publishedYes
Event2020 2nd International Conference on Computer Modeling, Simulation and Algorithm, CMSA 2020 - Beijing, China
Duration: 21 Jun 202022 Jun 2020

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