Refining psychiatric genetics: From 'mouse psychiatry' to understanding complex human disorders

Justin L. Laporte, Renee F. Ren-Patterson, Dennis L. Murphy, Allan V. Kalueff

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Investigating the pathogenesis of psychiatric disorders is a complicated and rigorous task for psychiatric geneticistsas the disorders often involve combinations of genetic, behavioral, personality, and environmental factors. To nurture further progress in this field, a new set of conceptual tools is needed in addition to the currently accepted approaches. Concepts that consider cross-species trait genetics and the interplay between the domains of disorders, as well as the full spectrum of potential symptoms and their place along the pathogenetic continuum, are particularly important to address these needs. Here, we outline recent concepts and approaches that can help refine the field and enable more precise dissection of the genetic mechanisms contributing to psychiatric disorders.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalBehavioural Pharmacology
Issue number5-6
Publication statusPublished - Sept 2008
Externally publishedYes


  • Behavioral domains
  • Genetic factors
  • Psychiatric disorders
  • Spectrum nature of pathogenesis


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