Recent Progress in Polymeric AIE-Active Drug Delivery Systems: Design and Application

Yang Pei, Ziyu Wang, Cheng Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Aggregation-induced emission (AIE) provides a new opportunity to overcome the drawbacks of traditional aggregation-induced quenching of chromophores. The applications of AIE-active fluorophores have spread across various fields. In particular, the employment of AIEgens in drug delivery systems (DDSs) can achieve imaging-guided therapy and pharmacodynamic monitoring. As a result, polymeric AIE-active DDSs are attracting increasing attention due to their obvious advantages, including easy fabrication and tunable optical properties by molecular design. Additionally, the design of polymeric AIE-active DDSs is a promising method for cancer therapy, antibacterial treatment, and pharmacodynamic monitoring, which indeed helps improve the effectiveness of related disease treatments and confirms its potential social importance. Here, we summarize the current available polymeric AIE-active DDSs from design to applications. In the design section, we introduce synthetic strategies and structures of AIE-active polymers, as well as responsive strategies for specific drug delivery. In the application section, typical polymeric AIE-active DDSs used for cancer therapy, bacterial treatment, and drug delivery monitoring are summarized with selected examples to elaborate on their wide applications.

Original languageEnglish
Pages (from-to)3951-3965
Number of pages15
JournalMolecular Pharmaceutics
Volume18
Issue number11
DOIs
Publication statusPublished - 1 Nov 2021
Externally publishedYes

Keywords

  • aggregation-induced emission
  • AIE-active polymer
  • bacterial treatment
  • cancer therapy
  • drug delivery monitoring
  • drug delivery system
  • peacebuilding

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