Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion

Xinglei Liu, Xiaoxiao Dai, Chungang Dai, Qin Zhu, Ailin Chen, Yanming Chen, Nan Chen, Ping Chen, Rong Rong, Changjun Shi, Sheng Xiao, Jun Dong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Pilocytic astrocytoma is mostly a pediatric tumor with the majority of patients under age 20. Although tumors can occur throughout neuraxis, most tumors are in the cerebellum and optic chiasm. Pilocytic astrocytoma in unusual locations is often associated with different genetic alterations than the classic KIAA1549::BRAF fusion. We report a rare adult pilocytic astrocytoma of the septum pellucidum that presented with progressive headache. A detailed genomic evaluation found a fusion between BRAF and a novel partner RIN2, a gene overexpressed in both low-grade glioma and glioblastoma. The RIN2::BRAF transcript encodes a chimeric protein containing a dimerization domain SH2 and an intact kinase domain, consistent with a prototypic oncogenic kinase rearrangement. In addition, we discuss the potential oncogenic mechanisms of BRAF signaling and its implication in targeted therapy with kinase inhibitors.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalVirchows Archiv
Issue number2
Publication statusPublished - Feb 2023


  • Adult pilocytic astrocytoma
  • Pellucid septum
  • RIN2::BRAF fusion


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