Quinoxaline-2,3-diones: Potential D-amino acid oxidase (DAAO) inhibitors

Dongsheng Xie, Yanchao Wang, Jin Xie, Jun Lu, Junjun Cui, Man Zhang, Lei Fu*, Yongxiang Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A family of quinoxaline-2,3-diones was prepared and evaluated to exhibit D-amino acid oxidase (DAAO) inhibitory activities with IC50 values ranging from 0.6 to 15 μM in vitro. SAR analysis revealed their binding modes with DAAO and provided an important clue for further design of highly potent DAAO inhibitors with novel structures.

Original languageEnglish
Pages (from-to)4977-4989
Number of pages13
JournalMedicinal Chemistry Research
Issue number11
Publication statusPublished - Nov 2014
Externally publishedYes


  • D-Amino acid oxidase
  • DAAO
  • DAAO inhibitors
  • Quinoxaline-2,3-diones

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