Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

K. Douroudis; E. Prans; K. Haller; V. Nemvalts; T. Rajasalu; V. Tillmann; K. Kisand; R. Uibo

doi:10.1111/j.1399-0039.2008.01115.x

Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

K. Douroudis, E. Prans, K. Haller, V. Nemvalts, T. Rajasalu, V. Tillmann, K. Kisand, R. Uibo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is considered an important regulator of T-cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls. Using two methods for PTPN22 C1858T detection in parallel, we found that not only T1D but also T2D is associated with the PTPN22 1858T allele. The role of PTPN22 gene in the pathogenesis of T2D is yet unclear and needs further investigation.

Original language	English
Pages (from-to)	425-430
Number of pages	6
Journal	Tissue Antigens
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-0039.2008.01115.x
Publication status	Published - Nov 2008
Externally published	Yes

Keywords

Protein tyrosine phosphatase non-receptor type 22
Single nucleotide polymorphism
Type 1 diabetes
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1399-0039.2008.01115.x

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title = "Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population",

abstract = "Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is considered an important regulator of T-cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls. Using two methods for PTPN22 C1858T detection in parallel, we found that not only T1D but also T2D is associated with the PTPN22 1858T allele. The role of PTPN22 gene in the pathogenesis of T2D is yet unclear and needs further investigation.",

keywords = "Protein tyrosine phosphatase non-receptor type 22, Single nucleotide polymorphism, Type 1 diabetes, Type 2 diabetes",

author = "K. Douroudis and E. Prans and K. Haller and V. Nemvalts and T. Rajasalu and V. Tillmann and K. Kisand and R. Uibo",

year = "2008",

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doi = "10.1111/j.1399-0039.2008.01115.x",

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T1 - Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

AU - Douroudis, K.

AU - Prans, E.

AU - Haller, K.

AU - Nemvalts, V.

AU - Rajasalu, T.

AU - Tillmann, V.

AU - Kisand, K.

AU - Uibo, R.

PY - 2008/11

Y1 - 2008/11

N2 - Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is considered an important regulator of T-cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls. Using two methods for PTPN22 C1858T detection in parallel, we found that not only T1D but also T2D is associated with the PTPN22 1858T allele. The role of PTPN22 gene in the pathogenesis of T2D is yet unclear and needs further investigation.

AB - Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is considered an important regulator of T-cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls. Using two methods for PTPN22 C1858T detection in parallel, we found that not only T1D but also T2D is associated with the PTPN22 1858T allele. The role of PTPN22 gene in the pathogenesis of T2D is yet unclear and needs further investigation.

KW - Protein tyrosine phosphatase non-receptor type 22

KW - Single nucleotide polymorphism

KW - Type 1 diabetes

KW - Type 2 diabetes

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ER -

Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

Abstract

Keywords

UN SDGs

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