Preparation, characterization and biological evaluation of azido-seconucleoside analogues

Xu Ran*, Yong Bai, Yao Chen, Fa Qin Jiang, Jian Cun Zhang, Lei Fu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To synthetize 2′,3′-azido-2′,3′- seconucleoside analogues, and to determine the potential antiviral activity. Methods: The target compounds were synthesized from natural nucleosides, through sulfonylation at 2′,3′-OH and nucleophilic substitution by NaN 3. Results and Conclusion: The structures of these compounds were confirmed by 1H NMR, 13C NMR and HRMS analyses. All the target compounds showed moderate anti-HSV-I activity, which might contribute to the research on SAR of nucleosides analogues in this field.

Original languageEnglish
Pages (from-to)1995-1998+2001
JournalChinese Journal of New Drugs
Issue number20
Publication statusPublished - 30 Oct 2009
Externally publishedYes


  • Azido
  • Characterization
  • Evaluation
  • Preparation
  • Seconucleosides

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