Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective

Mahmoud A. Ebada; Abdalrhman Mostafa; Al Hussein A. Gadallah; Souad Alkanj; Badrah S. Alghamdi; Ghulam Md Ashraf; Adel M. Abuzenadah; Raed F. Alserihi; Ahmed Wadaa-Allah; Mohamed Salama

doi:10.3390/brainsci13020243

Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective

Mahmoud A. Ebada^*, Abdalrhman Mostafa, Al Hussein A. Gadallah, Souad Alkanj, Badrah S. Alghamdi, Ghulam Md Ashraf, Adel M. Abuzenadah, Raed F. Alserihi, Ahmed Wadaa-Allah, Mohamed Salama

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.

Original language	English
Article number	243
Journal	Brain Sciences
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/brainsci13020243
Publication status	Published - Feb 2023
Externally published	Yes

Keywords

compounds
estrogenic
miRNA-29
miRNA-9
regulation

Access to Document

10.3390/brainsci13020243

Cite this

@article{710cd701fc674013a51b9296ae1e9717,

title = "Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective",

abstract = "Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.",

keywords = "compounds, estrogenic, miRNA-29, miRNA-9, regulation",

author = "Ebada, {Mahmoud A.} and Abdalrhman Mostafa and Gadallah, {Al Hussein A.} and Souad Alkanj and Alghamdi, {Badrah S.} and Ashraf, {Ghulam Md} and Abuzenadah, {Adel M.} and Alserihi, {Raed F.} and Ahmed Wadaa-Allah and Mohamed Salama",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = feb,

doi = "10.3390/brainsci13020243",

language = "English",

volume = "13",

journal = "Brain Sciences",

issn = "2076-3425",

number = "2",

}

TY - JOUR

T1 - Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders

T2 - An Insightful Perspective

AU - Ebada, Mahmoud A.

AU - Mostafa, Abdalrhman

AU - Gadallah, Al Hussein A.

AU - Alkanj, Souad

AU - Alghamdi, Badrah S.

AU - Ashraf, Ghulam Md

AU - Abuzenadah, Adel M.

AU - Alserihi, Raed F.

AU - Wadaa-Allah, Ahmed

AU - Salama, Mohamed

PY - 2023/2

Y1 - 2023/2

N2 - Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.

AB - Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.

KW - compounds

KW - estrogenic

KW - miRNA-29

KW - miRNA-9

KW - regulation

UR - http://www.scopus.com/inward/record.url?scp=85148902245&partnerID=8YFLogxK

U2 - 10.3390/brainsci13020243

DO - 10.3390/brainsci13020243

M3 - Review article

AN - SCOPUS:85148902245

SN - 2076-3425

VL - 13

JO - Brain Sciences

JF - Brain Sciences

IS - 2

M1 - 243

ER -

Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this