Potent transglutaminase inhibitors, dithio β-aminoethyl ketones

Shoichiro Ozaki, Etsuko Ebisui, Kozo Hamada, Akinobu Z. Suzuki, Akiko Terauchi, Katsuhiko Mikoshiba*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - 1 Jan 2011
Externally publishedYes


  • Alzheimer's disease
  • Celiac disease
  • Dithio β-aminoethyl ketones
  • Huntington's disease
  • Parkinson's disease
  • Transglutaminase inhibitors


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