Potent transglutaminase inhibitors, aryl β-aminoethyl ketones

Shoichiro Ozaki, Etsuko Ebisui, Kozo Hamada, Jun Ichi Goto, Akinobu Z. Suzuki, Akiko Terauchi, Katsuhiko Mikoshiba*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Aryl β-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl β-aminoethyl ketones.

Original languageEnglish
Pages (from-to)1141-1144
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
Publication statusPublished - 1 Feb 2010
Externally publishedYes


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