Platelet-mediated modulation of adaptive immunity: A communication link between innate and adaptive immune compartments

Bennett D. Elzey, Jun Tian, Robert J. Jensen, Axel K. Swanson, Jason R. Lees, Steven R. Lentz, Colleen S. Stein, Bernhard Nieswandt, Yiqiang Wang, Beverly L. Davidson, Timothy L. Ratliff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

341 Citations (Scopus)

Abstract

Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through the release of chemokines, cytokines, and a number of immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity. The data reported herein demonstrate that platelets, via CD154, induce dendritic cell maturation, B cell isotype switching, and augment CD8+ T cell responses both in vitro and in vivo. Platelet transfusion studies demonstrate that platelet-derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function during viral infection, leading to enhanced protection against viral rechallenge. Additionally, depletion of platelets in normal mice results in decreased antigen-specific antibody production.

Original languageEnglish
Pages (from-to)9-19
Number of pages11
JournalImmunity
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Jul 2003
Externally publishedYes

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