Photoacoustic-fluorescence microendoscopy in vivo

Wenzhao Yang, Jiasheng Zhou, Weihao Shao, Myeongsu Seong, Pengbo He, Zhanhong Ye, Zhendong Guo, Lili Jing, Sung Liang Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A miniature endoscope capable of imaging multiple tissue contrasts in high resolution is highly attractive, because it can provide complementary and detailed tissue information of internal organs. Here we present a photoacoustic (PA)-fluorescence (FL) endoscope for optical-resolution PA microscopy (PAM) and FL microscopy (FLM). The endoscope with a diameter of 2.8 mm achieves high lateral resolutions of 5.5 and 6.3 µm for PAM and FLM modes, respectively. In vivo imaging of zebrafish larvae and a mouse ear is conducted, and high-quality images are obtained. Additionally, in vivo endoscopic imaging of a rat rectum is demonstrated, showing the endoscopic imaging capability of our endoscope. By providing dual contrasts with high resolution, the endoscope may open up new opportunities for clinical endoscopic imaging applications.

Original languageEnglish
Pages (from-to)2340-2343
Number of pages4
JournalOptics Letters
Issue number10
Publication statusPublished - 15 May 2021
Externally publishedYes


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