Phosphinic acids: current status and potential for drug discovery

Moaz M. Abdou, Paul M. O'Neill, Eric Amigues, Magdalini Matziari*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)


Phosphinic acid derivatives exhibit diverse biological activities and a high degree of structural diversity, rendering them a versatile tool in the development of new medicinal agents. Pronounced recent progress, coupled with previous research findings, highlights the impact of this moiety in medicinal chemistry. Here, we highlight the most important breakthroughs made with phosphinates with a range of pharmacological activities against many diseases, including anti-inflammatory, anti-Alzheimer, antiparasitic, antihepatitis, antiproliferative, anti-influenza, anti-HIV, antimalarial, and antimicrobial agents.

Original languageEnglish
Pages (from-to)916-929
Number of pages14
JournalDrug Discovery Today
Issue number3
Publication statusPublished - Mar 2019


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