Phenotyping of zebrafish homebase behaviors in novelty-based tests

Adam Stewart, Jonathan M. Cachat, Keith Wong, Nadine Wu, Leah Grossman, Christopher Suciu, Jason Goodspeed, Marco F. Elegante, Brett K. Bartels, Salem I. Elkhayat, David H. Tien, Siddharth Gaikwad, Ferdous Kadri, Kyung Min Chung, Julia Tan, Ashley Denmark, Thomas Gilder, John Dileo, Katie Chang, Kevin FrankEli Utterback, Patrick Viviano, Allan V. Kalueff

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review

7 Citations (Scopus)


Various novelty-based assays used to quantify zebrafish (Danio rerio) behavior show a striking similarity to behavioral responses in rodents. Exposed to the open field test, zebrafish establish overt homebases demonstrating clear preference for a particular area of the tank. This behavior aims to establish a "safe zone" that zebrafish can familiarize themselves with and feel secure in, and is similar to homebase behaviors of various laboratory rodent species. Here we outline a simple protocol for homebase phenotyping in zebrafish.

Original languageEnglish
Title of host publicationZebrafish Neurobehavioral Protocols
EditorsAllan Kalueff, Jonathan Cachat
Number of pages13
Publication statusPublished - 2011
Externally publishedYes

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • cognitive maps
  • exploration
  • homebase behavior
  • open field test
  • spatial orientation
  • Zebrafish


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