Pharmacological modulation of anxiety-related behaviors in the murine Suok test

A. V. Kalueff*, T. Keisala, A. Minasyan, P. Tuohimaa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We have recently introduced a new model of anxiety - the Suok test and its light-dark modification - for behavioral characterization in mice and rats, including simultaneous assessment of their anxiety, activity, and neurological phenotypes. In the present study, testing different inbred (129S1, BALB/c) and hybrid (C57-129S1) mouse strains in both Suok test modifications, we examined the effects on anxiety-related behaviours produced by traditional anxiogenic and anxiolytic drugs. Here we show dose-dependent increases in anxiety-related behaviors produced by anxiogenic drug pentylenetetrazole (10 and 20 mg/kg). In contrast, anxiolytic drugs ethanol (0.75 and 1.5 g/kg) and diazepam (0.5 mg/kg) reduced anxiety and increased mouse exploration in this test. Hyperemotional anxious BALB/c mice were particularly sensitive to pharmacogenic anxiety in Suok test, also showing robust light-dark shifts in the light-dark version of this test. Overall, the results of this study confirm the potential utility of both murine Suok tests, especially when used in selected "sensitive" mouse strains, for high-throughput screening of potential anxiotropic drugs.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalBrain Research Bulletin
Issue number1-3
Publication statusPublished - 14 Sept 2007
Externally publishedYes


  • Anxiety
  • Drug-evoked alterations
  • Light-dark modification
  • Mice
  • Suok test


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