TY - JOUR
T1 - Perspective on human pluripotent stem cell-derived cardiomyocytes in heart disease modeling and repair
AU - Li, Qiang
AU - Wang, Jia
AU - Wu, Qiang
AU - Cao, Nan
AU - Yang, Huang Tian
N1 - Publisher Copyright:
© 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals, Inc. on behalf of AlphaMed Press
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human pluripotent stem cell (hPSC) biology and technology that allow the efficient preparation of cardiomyocytes from individual patients, tremendous efforts have been made for using hPSC-derived cardiomyocytes in preclinical and clinical cardiac therapy as well as in dissection of HD mechanisms to develop new methods for disease prediction and treatment. However, their applications have been hampered by several obstacles. Here, we discuss recent advances, remaining challenges, and the potential solutions to advance this field.
AB - Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human pluripotent stem cell (hPSC) biology and technology that allow the efficient preparation of cardiomyocytes from individual patients, tremendous efforts have been made for using hPSC-derived cardiomyocytes in preclinical and clinical cardiac therapy as well as in dissection of HD mechanisms to develop new methods for disease prediction and treatment. However, their applications have been hampered by several obstacles. Here, we discuss recent advances, remaining challenges, and the potential solutions to advance this field.
KW - cardiac
KW - cell transplantation
KW - differentiation
KW - embryonic stem cells (ESCs)
KW - induced pluripotent stem cells (iPSCs)
KW - pluripotent stem cells
KW - tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=85088576594&partnerID=8YFLogxK
U2 - 10.1002/sctm.19-0340
DO - 10.1002/sctm.19-0340
M3 - Review article
C2 - 32725800
AN - SCOPUS:85088576594
SN - 2157-6564
VL - 9
SP - 1121
EP - 1128
JO - Stem Cells Translational Medicine
JF - Stem Cells Translational Medicine
IS - 10
ER -