Perceptual learning improves contrast sensitivity and visual acuity in adults with anisometropic amblyopia

Yifeng Zhou*, Changbing Huang, Pengjing Xu, Liming Tao, Zhuping Qiu, Xiangrui Li, Zhong Lin Lu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

220 Citations (Scopus)


To evaluate the effects of perceptual learning on contrast-sensitivity function and visual acuity in adult observers with amblyopia, 23 anisometropic amblyopes with a mean age of 19.3 years were recruited and divided into three groups. Subjects in Group I were trained in grating detection in the amblyopic eye near pre-training cut-off spatial frequency. Group II received a training regimen of repeated contrast-sensitivity function measurements in the amblyopic eye. Group III received no training. We found that training substantially improved visual acuity and contrast-sensitivity functions in the amblyopic eyes of all the observers in Groups I and II, although no significant performance improvement was observed in Group III. For observers in Group I, performance improvements in the amblyopic eyes were broadly tuned in spatial frequency and generalized to the fellow eyes. The latter result was not found in Group II. In a few cases tested, improvements in visual acuity following training showed about 90% retention for at least 1 year. We concluded that the visual system of adult amblyopes might still retain substantial plasticity. Perceptual learning shows potential as a clinical tool for treating child and adult amblyopia.

Original languageEnglish
Pages (from-to)739-750
Number of pages12
JournalVision Research
Issue number5
Publication statusPublished - Mar 2006
Externally publishedYes


  • Amblyopia
  • Contrast detection
  • Contrast sensitivity
  • Perceptual learning
  • Visual acuity


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