Organic selenium ameliorates non-alcoholic fatty liver disease through 5-hydroxytryptamine/bile acid enterohepatic circulation in mice

Lin Zhang; Jing Bo Fan; Xin Wen Zhang; Yu Liu; Wen Yao Shi; Khemayanto Hidayat; Jia Ying Xu; Linxi Yuan; Li Qiang Qin

doi:10.1016/j.jff.2023.105596

Organic selenium ameliorates non-alcoholic fatty liver disease through 5-hydroxytryptamine/bile acid enterohepatic circulation in mice

Lin Zhang, Jing Bo Fan, Xin Wen Zhang, Yu Liu, Wen Yao Shi, Khemayanto Hidayat, Jia Ying Xu, Linxi Yuan, Li Qiang Qin^*

^*Corresponding author for this work

Department of Health and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To investigate the effects of organic selenium (L-selenocystine, L-selenomethionine, and L-selenomethylcysteine) on non-alcoholic fatty liver disease (NAFLD), the NAFLD mice model with hepatic steatosis and fibrosis was established via feeding with a Western diet and CCl₄ injection. Compared with the model group, the intervention groups with organic selenium experienced a reduction in hepatic 5-hydroxytryptophan (5-HT) contents and downregulation in the expression of tryptophan hydroxylase 1 (TPH1) and 5-HT receptor 2A/2B/3A. Similar results were observed on TPH1/5-HT in the duodenum. In addition, organic selenium decreased the bile acid (BA) concentrations in gut contents, downregulated the expression of hepatic CYP7A1, and upregulated the expression of hepatic Farnesoid X‐activated receptor (FXR). In conclusion, our findings suggest that organic selenium ameliorates NAFLD through 5-HT/BA enterohepatic circulation in mice with NAFLD.

Original language	English
Article number	105596
Journal	Journal of Functional Foods
Volume	106
DOIs	https://doi.org/10.1016/j.jff.2023.105596
Publication status	Published - Jul 2023

Keywords

5-Hydroxytryptophan
Bile acids
Non-alcoholic fatty liver disease
Organic selenium

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10.1016/j.jff.2023.105596

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@article{873148d51f2a4e2eb22723846f84fe79,

title = "Organic selenium ameliorates non-alcoholic fatty liver disease through 5-hydroxytryptamine/bile acid enterohepatic circulation in mice",

abstract = "To investigate the effects of organic selenium (L-selenocystine, L-selenomethionine, and L-selenomethylcysteine) on non-alcoholic fatty liver disease (NAFLD), the NAFLD mice model with hepatic steatosis and fibrosis was established via feeding with a Western diet and CCl4 injection. Compared with the model group, the intervention groups with organic selenium experienced a reduction in hepatic 5-hydroxytryptophan (5-HT) contents and downregulation in the expression of tryptophan hydroxylase 1 (TPH1) and 5-HT receptor 2A/2B/3A. Similar results were observed on TPH1/5-HT in the duodenum. In addition, organic selenium decreased the bile acid (BA) concentrations in gut contents, downregulated the expression of hepatic CYP7A1, and upregulated the expression of hepatic Farnesoid X‐activated receptor (FXR). In conclusion, our findings suggest that organic selenium ameliorates NAFLD through 5-HT/BA enterohepatic circulation in mice with NAFLD.",

keywords = "5-Hydroxytryptophan, Bile acids, Non-alcoholic fatty liver disease, Organic selenium",

author = "Lin Zhang and Fan, {Jing Bo} and Zhang, {Xin Wen} and Yu Liu and Shi, {Wen Yao} and Khemayanto Hidayat and Xu, {Jia Ying} and Linxi Yuan and Qin, {Li Qiang}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = jul,

doi = "10.1016/j.jff.2023.105596",

language = "English",

volume = "106",

journal = "Journal of Functional Foods",

issn = "1756-4646",

}

TY - JOUR

T1 - Organic selenium ameliorates non-alcoholic fatty liver disease through 5-hydroxytryptamine/bile acid enterohepatic circulation in mice

AU - Zhang, Lin

AU - Fan, Jing Bo

AU - Zhang, Xin Wen

AU - Liu, Yu

AU - Shi, Wen Yao

AU - Hidayat, Khemayanto

AU - Xu, Jia Ying

AU - Yuan, Linxi

AU - Qin, Li Qiang

PY - 2023/7

Y1 - 2023/7

N2 - To investigate the effects of organic selenium (L-selenocystine, L-selenomethionine, and L-selenomethylcysteine) on non-alcoholic fatty liver disease (NAFLD), the NAFLD mice model with hepatic steatosis and fibrosis was established via feeding with a Western diet and CCl4 injection. Compared with the model group, the intervention groups with organic selenium experienced a reduction in hepatic 5-hydroxytryptophan (5-HT) contents and downregulation in the expression of tryptophan hydroxylase 1 (TPH1) and 5-HT receptor 2A/2B/3A. Similar results were observed on TPH1/5-HT in the duodenum. In addition, organic selenium decreased the bile acid (BA) concentrations in gut contents, downregulated the expression of hepatic CYP7A1, and upregulated the expression of hepatic Farnesoid X‐activated receptor (FXR). In conclusion, our findings suggest that organic selenium ameliorates NAFLD through 5-HT/BA enterohepatic circulation in mice with NAFLD.

AB - To investigate the effects of organic selenium (L-selenocystine, L-selenomethionine, and L-selenomethylcysteine) on non-alcoholic fatty liver disease (NAFLD), the NAFLD mice model with hepatic steatosis and fibrosis was established via feeding with a Western diet and CCl4 injection. Compared with the model group, the intervention groups with organic selenium experienced a reduction in hepatic 5-hydroxytryptophan (5-HT) contents and downregulation in the expression of tryptophan hydroxylase 1 (TPH1) and 5-HT receptor 2A/2B/3A. Similar results were observed on TPH1/5-HT in the duodenum. In addition, organic selenium decreased the bile acid (BA) concentrations in gut contents, downregulated the expression of hepatic CYP7A1, and upregulated the expression of hepatic Farnesoid X‐activated receptor (FXR). In conclusion, our findings suggest that organic selenium ameliorates NAFLD through 5-HT/BA enterohepatic circulation in mice with NAFLD.

KW - 5-Hydroxytryptophan

KW - Bile acids

KW - Non-alcoholic fatty liver disease

KW - Organic selenium

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U2 - 10.1016/j.jff.2023.105596

DO - 10.1016/j.jff.2023.105596

M3 - Article

AN - SCOPUS:85160510310

SN - 1756-4646

VL - 106

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 105596

ER -

Organic selenium ameliorates non-alcoholic fatty liver disease through 5-hydroxytryptamine/bile acid enterohepatic circulation in mice

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Keywords

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